VIDEOS & RESOURCES > RESOURCES

ONLINE RESOURCES AND DOWNLOADS

YOUR GO-TO MAYZENT RESOURCES

Check out all available resources to learn about MAYZENT® and relapsing multiple sclerosis (RMS). Find community support and more–all in one place.

SPOTLIGHT ON MAYZENT VIDEO SERIES

Watch this on-demand video series to hear all about MAYZENT and relapsing MS (RMS) from people taking MAYZENT and MS experts.

Watch this on-demand video series to hear all about MAYZENT and relapsing MS (RMS) from people taking MAYZENT and MS experts.

DOWNLOADABLE RESOURCES

EXPLORING MAYZENT

MAYZENT DISCUSSION GUIDE

MAYZENT Doctor Discussion Guide

MAYZENT DISCUSSION GUIDE

Create a personalized discussion guide that you and your doctor can use to discuss your changing RMS and MAYZENT.

DISCOVER MAYZENT BROCHURE

Discover MAYZENT Brochure

DISCOVER MAYZENT BROCHURE

Everything you need to know about MAYZENT all in one downloadable brochure.

Everything you need to know about MAYZENT all in one downloadable brochure.

THE CAREGIVER’S GUIDEBOOK

MAYZENT caregiver guidebook

THE CAREGIVER’S GUIDEBOOK

Download this guide to help you navigate a loved one’s journey with MS.

Download this guide to help you navigate a loved one’s journey with MS.

READY TO START MAYZENT

READY TO START MAYZENT BROCHURE

Ready to start MAYZENT brochure

READY TO START MAYZENT BROCHURE

A step-by-step guide to begin
treatment with MAYZENT.

START
FORM

START
FORM

Once your doctor submits this Start Form, you'll be automatically enrolled in our support program.

Once your doctor submits this Start Form, you’ll be automatically enrolled in our support program.

MAYZENT TITRATION GUIDE

MAYZENT Titration Guide

MAYZENT TITRATION GUIDE

Get information on dosing with MAYZENT–how it works and what to know.

Get information on dosing with MAYZENT–how it works and what to know.

TOOLS FOR VIRTUAL VISITS

YOUR MS QUESTIONNAIRE

Thumbnail of MAYZENT Your Multiple Sclerosis Questionnaire

YOUR MS QUESTIONNAIRE

An interactive tool to help identify changing MS and prepare for a productive conversation with a neurologist.

An interactive tool to help identify changing MS and prepare for a productive conversation with a neurologist.

TELEMEDICINE CHECKLIST

Thumbnail of MAYZENT Telemedicine Checklist

TELEMEDICINE CHECKLIST

As virtual visits become more popular, use these tips to help optimize your experience.

As virtual visits become more popular, use these tips to help optimize your experience.

SHARE YOUR STORY

We want to hear your MAYZENT story. Become a MAYZENT Mentor as part of the Inspired Moments Network, and empower yourself to share your experience with RMS and the treatment journey with MAYZENT. You’ll also have the opportunity to be featured in communication materials on behalf of MAYZENT.

GO-TO MS WEBSITES

Find comprehensive information about MS, Walk MS®, FAQs, the latest findings in clinical research, and advocacy and volunteer opportunities.

Every step toward fighting MS counts. Join an MS walk or invite loved ones to participate—it’s for a good cause and very fun! Whether your event is in-person or virtual, show your support and join a walk in cities throughout the country.

MSAA is a reliable resource for the entire MS community, improving lives today through vital services and support, including a toll-free helpline, funding for magnetic resonance imaging (MRI), safety and mobility equipment, cooling vests, and educational information.

A nonprofit organization focused on providing individuals with MS any help they need to maintain their health, well-being, and quality of life.

A personalized program dedicated to helping people with MS and their care partners. The program can help address unique physical, emotional, and social needs while providing tips, support, and knowledge.

This organization keeps people with MS and their loved ones up to date on the latest MS research and provides information through a monthly e-newsletter, the MS Learning Channel on YouTube, their website, blog, and social media.

GLOSSARY

TYPES OF MULTIPLE SCLEROSIS (MS)

Active secondary progressive multiple sclerosis (active SPMS)

The early stage of SPMS, in which people experience fewer relapses but don't bounce back as well between relapses, and have increased disability. Active SPMS means a person may have had at least 1 relapse in the last 2 years.

Clinically isolated syndrome (CIS)

When you experience MS-like symptoms caused by inflammation and damage to myelin, but a definite diagnosis of MS cannot yet be made.

Relapsing multiple sclerosis (RMS)

A general term used for all forms of MS that have distinct episodes of relapses, including CIS, RRMS, and active SPMS.

Relapsing-remitting multiple sclerosis (RRMS)

The most common type of MS, characterized by episodes during which symptoms get worse (relapses) but are then followed by periods of recovery (remissions). About 85% of people with MS are first diagnosed with RRMS.

Secondary progressive multiple sclerosis (SPMS)

An advanced stage of MS that follows active SPMS, in which symptoms and disability often get worse with or without relapses.

OTHER TERMS ASSOCIATED WITH MS

Central nervous system (CNS)

The system in your body made up of the brain, spinal cord, and optic nerve.

Clinical study

A controlled study environment to document and understand if a drug is effective and evaluate its safety and side effects.

Confirmed disability progression (CDP)

Any change in disability that remains consistent over a certain period of time.

Disability progression

Lingering or worsening of symptoms between relapses and over time, that leads to increased cognitive and physical disability.

Expanded Disability Status Scale (EDSS)

The EDSS is a method of measuring disability progression and monitoring changes in the level of disability over time. It is widely used in clinical studies and in the assessment of people living with multiple sclerosis (MS).

Inflammation

Part of your body's immune response to help protect from infection. In certain conditions such as MS, your immune system attacks your body's own tissue by mistake, and resulting inflammation causes nerve damage.

Lymph nodes

Lumps of tissue located throughout the body that contain white bloods cells (lymphocytes) and fight infections as part of the body's immune system.

Lymphocytes

A type of white blood cell that plays several roles in the immune system, including protection against bacteria, viruses, fungi, and parasites.

Macular edema

A build-up of fluid in the eyes that can cause swelling and vision problems.

Myelin

A protective, insulating sheath that coats nerve cells.

Neurodegeneration

Nerve damage in the central nervous system (brain and spinal cord).

Permanent disability

Irreversible cognitive and physical symptoms.

Placebo

A baseline inactive treatment given to one group in clinical trials to help researchers understand the efficacy of a new medical treatment.

Progression

The shift from less inflammation and relapses to increased nerve damage, this can lead to worsening cognitive and physical symptoms that accumulate over time.

Relapse

Also called a "flare-up" or "exacerbation," an episode in which MS symptoms get worse, or new ones arise, for a period of 1 day to several months, followed by at least 30 days of stability.

Titration

Slowly increasing the dose of your medication to help your body adjust.

T2 lesions

T2 lesions, also called plaques, can be detected on MRI scans to measure disease activity in multiple sclerosis (MS).

ALONGSIDE MAYZENT BENEFITS

Join Alongside™ MAYZENT for personalized support. We'll help with treatment, check if you're eligible for $0 co-pay, and more.

QUESTIONS? FIND ANSWERS HERE

Check out our FAQ page to find answers to questions that people commonly have about MAYZENT.

IMPORTANT SAFETY INFORMATION AND INDICATION

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IMPORTANT SAFETY INFORMATION

Do not take MAYZENT if you:

  • have a CYP2C9*3/*3 genotype. Before starting treatment with MAYZENT, your CYP2C9 genotype should be determined by your health care provider. Ask your health care provider if you are not sure.

  • have had a heart attack, chest pain called unstable angina, stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months

What is MAYZENT® (siponimod) tablets?

MAYZENT is a prescription medicine that is used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if MAYZENT is safe and effective in children.

  • have certain types of heart block or irregular or abnormal heartbeat (arrhythmia), unless you have a pacemaker

MAYZENT may cause serious side effects, including:

  1. Slow heart rate (bradycardia or bradyarrhythmia) when you start taking MAYZENT. MAYZENT can cause your heart rate to slow down, especially after you take your first dose. You should have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of MAYZENT.

    During the initial updosing period (4 days for the 1-mg daily dose or 5 days for the 2-mg daily dose), if you miss 1 or more doses of MAYZENT, you need to restart the updosing. Call your health care provider if you miss a dose of MAYZENT.

  2. Infections. MAYZENT can increase your risk of serious infections that can be life-threatening and cause death. MAYZENT lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 to 4 weeks of stopping treatment. Your health care provider should review a recent blood test of your white blood cells before you start taking MAYZENT.

    Call your health care provider right away if you have any of these symptoms of an infection during treatment with MAYZENT and for 3 to 4 weeks after your last dose of MAYZENT:

    • fever

    • tiredness

    • body aches

    • chills

    • nausea

    • vomiting

    • headache with fever, neck stiffness, sensitivity to light, nausea, confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)

  3. A problem with your vision called macular edema. Macular edema can cause some of the same vision symptoms as a multiple sclerosis (MS) attack (optic neuritis). You may not notice any symptoms with macular edema. If macular edema happens, it usually starts in the first 1 to 4 months after you start taking MAYZENT. Your health care provider should test your vision before you start taking MAYZENT and any time you notice vision changes during treatment with MAYZENT. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis.

    Call your health care provider right away if you have any of the following: blurriness or shadows in the center of your vision, a blind spot in the center of your vision, sensitivity to light, or unusually colored (tinted) vision.

Before taking MAYZENT, tell your health care provider about all of your medical conditions, including if you:

  • have an irregular or abnormal heartbeat

  • have a history of stroke or other diseases related to blood vessels in the brain

  • have breathing problems, including during your sleep

  • have a fever or infection, or you are unable to fight infections due to a disease or are taking medicines that lower your immune system. Tell your health care provider if you have had chickenpox or have received the vaccine for chickenpox. Your health care provider may do a blood test for chickenpox virus. You may need to get the full course of vaccine for chickenpox and then wait 1 month before you start taking MAYZENT.

  • have slow heart rate

  • have liver problems

  • have diabetes

  • have eye problems, especially an inflammation of the eye called uveitis

  • had or now have a type of skin cancer called basal cell carcinoma (BCC), melanoma, or squamous cell carcinoma

  • have high blood pressure

  • are pregnant or plan to become pregnant. MAYZENT may harm your unborn baby. Talk to your health care provider right away if you become pregnant while taking MAYZENT or if you become pregnant within 10 days after you stop taking MAYZENT.

    • If you are a woman who can become pregnant, you should use effective birth control during your treatment with MAYZENT and for at least 10 days after you stop taking MAYZENT.

  • are breastfeeding or plan to breastfeed. It is not known if MAYZENT passes into your breast milk. Talk to your health care provider about the best way to feed your baby if you take MAYZENT.

Tell your health care provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Especially tell your health care provider if you take medicines to control your heart rhythm (anti-arrhythmics), or blood pressure (antihypertensives), or heart beat (such as calcium channel blockers or beta-blockers); take medicines that affect your immune system, such as beta-interferon or glatiramer acetate, or any of these medicines that you took in the past.

Tell your health care provider if you have recently received a live vaccine. You should avoid receiving live vaccines during treatment with MAYZENT. MAYZENT should be stopped 1 week before and for 4 weeks after receiving a live vaccine. If you receive a live vaccine, you may get the infection the vaccine was meant to prevent. Vaccines may not work as well when given during treatment with MAYZENT.

MAYZENT may cause possible side effects, including:

  • increased blood pressure. Your health care provider should check your blood pressure during treatment with MAYZENT.

  • liver problems. MAYZENT may cause liver problems. Your health care provider should do blood tests to check your liver before you start taking MAYZENT. Call your health care provider right away if you have any of the following symptoms of liver problems:

    • nausea

    • vomiting

    • stomach pain

    • tiredness

    • loss of appetite

    • your skin or the whites of your eyes turn yellow

    • dark urine

  • breathing problems. Some people who take MAYZENT have shortness of breath. Call your health care provider right away if you have new or worsening breathing problems.

  • swelling and narrowing of the blood vessels in your brain. A condition called PRES (Posterior Reversible Encephalopathy Syndrome) has happened with drugs in the same class. Symptoms of PRES usually get better when you stop taking MAYZENT. However, if left untreated, it may lead to a stroke. Call your health care provider right away if you have any of the following symptoms: sudden severe headache, sudden confusion, sudden loss of vision or other changes in vision, or seizure.

  • severe worsening of multiple sclerosis after stopping MAYZENT. When MAYZENT is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your doctor before you stop taking MAYZENT for any reason. Tell your health care provider if you have worsening symptoms of MS after stopping MAYZENT.

  • a type of skin cancer called basal cell carcinoma (BCC), melanoma, and squamous cell carcinoma. Tell your doctor if you have any changes in the appearance of your skin, including changes in a mole, a new darkened area on your skin, a sore that does not heal, or growths on your skin, such as a bump that may be shiny, pearly white, skin-colored, or pink. Your doctor should check your skin for any changes during treatment with MAYZENT. Limit the amount of time you spend in sunlight and ultraviolet (UV) light. Wear protective clothing and use a sunscreen with a high sun protection factor.

The most common side effects of MAYZENT include: headache, high blood pressure (hypertension), and abnormal liver tests.

These are not all of the possible side effects of MAYZENT. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is MAYZENT® (siponimod) tablets?

MAYZENT is a prescription medicine that is used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if MAYZENT is safe and effective in children.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide.