IF YOU THINK YOUR RMS MIGHT BE CHANGING
How can I tell if my RMS is changing?
It's common for your RMS to change or progress over time. RMS progression can ultimately lead to increased physical disability and problems with thinking. Common signs to look for include:
You're having fewer relapses but disability is increasing
Your MS symptoms are getting worse, you're experiencing new ones, or they're lingering in between relapses
It's harder to do physical activities
The number of active lesions on your MRI has decreased
I've noticed my relapses becoming less frequent. Does this mean my RMS medication is working?
It might mean your medication is working, or it might mean something else. Keep in mind, everyone's MS is different and symptoms vary from person to person.
A confusing thing about RMS progression is that relapses or MRI lesions can become less frequent as disability increases.
It's best to speak with your doctor as soon as you notice any changes in your relapses.
What are common symptoms of disability progression in RMS?
RMS progression can ultimately lead to increased physical disability and problems with thinking. Signs of RMS progression may vary from person to person, but symptoms that commonly get worse or linger in between relapses include:
- Assistance required to walk
- Weakness or problems moving limbs
- Problems with coordination
- Bowel and bladder issues
- Trouble with memory or concentration
- Vision problems
- Difficulty with speech or swallowing
- Numbness or loss of sensation
Everyone experiences RMS differently, and other symptoms may appear.
IF YOU WANT TO KNOW MORE ABOUT MAYZENT
How can I know if once-daily MAYZENT is right for me and my RMS?
Your doctor is the one to determine if MAYZENT is a good fit for you. They may look at the MAYZENT clinical trial, as well as your medical history to decide. The MAYZENT clinical trial was the largest trial of people with relapsing MS progression, with 1651 people with secondary progressive MS (SPMS).
Could MAYZENT slow down disability progression?
MAYZENT is a once-daily pill proven to help slow down disability progression. The overall study result for 3-month confirmed disability progression was that nearly 3 out of 4 people taking MAYZENT showed no confirmed disability progression.* Learn more about the results from the 3-year MAYZENT clinical trial.
The effect of MAYZENT was significant in people who had a relapse in the 2 years before the study, but not considered significant in people who did not.
*Nearly 3 out of 4 is 74%, compared to 68% taking placebo.
How does MAYZENT work?
MAYZENT is a once-daily pill studied and proven in progressing RMS. It targets 2 key receptors in the brain and body believed to play roles in both inflammation and nerve damage (neurodegeneration). It attaches to certain receptors on immune cells and traps those inflammatory cells in your lymph nodes. This may minimize the damage those cells have on your nerves.†
Because of the way the body processes MAYZENT, your immune cell count will return to normal within 10 days after stopping treatment. MAYZENT may continue to lower immune cell count for up to 3-4 weeks after the last dose. Learn more about how MAYZENT works.
†The exact way that MAYZENT works on MS is unknown, but it is believed to involve reduction of lymphocytes in the central nervous system (CNS).
What should I know about MAYZENT safety?
There are side effects associated with taking MAYZENT, including some that are serious. MAYZENT may slow your heart rate when you start taking it. Your doctor should give you an electrocardiogram (ECG) before you take your first dose. MAYZENT may also increase your risk of infections that may be life-threatening and cause death. MAYZENT may also cause a problem with your vision called macular edema. Learn more about safety and side effects here, or in the MAYZENT Medication Guide.
Who should not take MAYZENT?
Some people cannot take MAYZENT, including those with a specific genotype called CYP2C9*3/*3 and certain heart conditions. Before starting treatment, your doctor will determine your genotype. Don't take MAYZENT if you've had a heart attack, a type of chest pain called unstable angina, stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months. If you've had certain types of heart block or irregular or abnormal heartbeat (arrhythmia) you also cannot take MAYZENT, unless you have a pacemaker.
Is there any support for me while I'm taking MAYZENT?
The moment your doctor submits a Start Form for MAYZENT, you'll be automatically enrolled in our support program called Alongside™ MAYZENT and paired with a dedicated Alongside MAYZENT Coordinator.
Your Coordinator will help you get started on MAYZENT and provide you with support along the way while you're on treatment. Find out more about Alongside MAYZENT.
IF YOU'RE STARTING MAYZENT
My doctor prescribed MAYZENT for me. What happens next?
Once your Start Form is submitted, you're automatically enrolled in the Alongside MAYZENT support program and paired with a Coordinator who will help you get started. They'll call you to walk through the steps to get started and answer any questions you may have along the way.
Your Coordinator will look into your insurance coverage and help schedule deliveries with your specialty pharmacy. You'll also need a few tests before taking your first dose of MAYZENT, which your Coordinator can help schedule.
What kind of tests will I have to take before starting MAYZENT?
There are 2 steps to complete before starting MAYZENT in order to get you off to a smooth start. The first step is pretests. Your Alongside MAYZENT Coordinator will help you schedule them at a time and place that works for you.
Routine blood test
Electrocardiogram (ECG)). See below for additional information based on ECG results.
These tests can take place in the comfort of your own home, your doctor's office, or a nearby medical facility. Learn more about pretests to get started.
What happens if my doctor wants me to be monitored during my first dose?
Depending on the results of your electrocardiogram (ECG), or if you have a history of certain heart issues, you may have to be monitored for a period of 6 hours after taking your first dose of MAYZENT.‡
If so, you'll have an ECG before taking your first dose and your pulse and blood pressure will be checked hourly. You'll then take a second ECG 6 hours after your first dose.
Results from this monitoring will determine if additional monitoring is needed or if you're ready to continue taking MAYZENT on a daily basis as your doctor prescribed.
‡For certain cardiac risk factors—for example, a history of heart attacks or heart failures—you may have to be monitored for a period of 6 hours after taking your first dose of MAYZENT. An ECG should be conducted at the end of the observation period.
How do I start taking MAYZENT?
Before you can start your maintenance dose, you'll have a 4- or 5-day titration period to help your body adjust to a new medication. On Day 1 you'll start with a low dose and gradually increase each day after the first 2 days until you reach your maintenance (full-strength) dose (either 1 or 2 mg). Learn more in the Ready to Start MAYZENT Brochure.
If you miss 1 or more doses of MAYZENT during the initial titration period, you'll need to restart the medication.
What else should I know about taking MAYZENT?
Here are some things you should know:
- Take MAYZENT once a day, with or without food
- If you miss 1 or more doses of MAYZENT during the initial titration period, you'll need to restart the medication and retake the blood tests
- If you miss a dose of MAYZENT after the initial titration period, take it as soon as you remember
- If you stop taking MAYZENT for 4 or more days in a row, you'll have to restart treatment with the titration period and retake the blood tests
- Always follow your doctor's instructions, and do not change your dose or stop taking MAYZENT unless your doctor tells you to
To learn more about taking MAYZENT, check out the Ready to Start MAYZENT Brochure.
How can I share my experience on MAYZENT with others?
Good question! The MAYZENT Mentor Network lets you connect to others with MS and hear their personal experiences with MAYZENT.
After you join,§ you'll have the opportunity to become a mentor and share your own story, as well as participate in photoshoots or speaking events. Learn more about the network.
§Joining this network is strictly voluntary. Your participation will not affect your medical care.
IF YOU NEED HELP PAYING FOR MAYZENT
Is there any financial support available to help me pay for MAYZENT?
Alongside MAYZENT will look into your insurance coverage and any savings offers you may qualify for. Depending on your insurance, some people will be eligible for a $0 co-pay offer or free medication while their coverage is sorted out.|| Find out more about MAYZENT financial support.
||Limitations apply. Valid only for those with private insurance. The Program includes the Co-Pay Card, Payment Card (if applicable), and Rebate, with a combined annual limit of $18,000. Patient is responsible for any costs once limit is reached in a calendar year. Program not valid (i) under Medicare, Medicaid, TRICARE, VA, DoD, or any other federal or state health care program, (ii) where patient is not using insurance coverage at all, or (iii) where the patient's insurance plan reimburses for the entire cost of the drug. The value of this Program is exclusively for the benefit of patients and is intended to be credited towards patient out-of-pocket obligations and maximums, including applicable co-payments, coinsurance, and deductibles. Program is not valid where prohibited by law. Patient may not seek reimbursement for the value received from this Program from other parties, including any health insurance program or plan, flexible spending account, or health care savings account. Patient is responsible for complying with any applicable limitations and requirements of their health plan related to the use of the Program. Valid only in the United States and Puerto Rico. This Program is not health insurance. Program may not be combined with any third-party rebate, coupon, or offer. Proof of purchase may be required. Novartis reserves the right to rescind, revoke, or amend the Program and discontinue support at any time without notice.
What if I don't have insurance coverage?
For people who are eligible, the Novartis Patient Assistance Foundation (NPAF) can provide free medication to those who are experiencing financial hardship and have limited or no prescription coverage.
Will my insurance cover MAYZENT?
While everyone's case is different, 4 out of 5 people who have a commercial or government insurance plan will be eligible for prescription coverage, with potential plan-specific requirements.
Currently, more than 85% of patient reimbursement claims are being approved¶ across all insurance providers.
¶As of June 16, 2020.
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